Skip to content Skip to sidebar Skip to footer

Title: Cellular Identity Crisis: The Role of Enhancers in Cancer


Introduction: Cancer arises when cells lose their normal function and uncontrollably divide. This loss of cellular identity is often associated with changes in gene expression, particularly in the regulation of enhancers. Enhancers are DNA sequences that control the activity of genes, acting as switches that turn genes on or off. Their precise arrangement and activity are crucial for determining cell identity.

Enhancers and Cell Identity: Enhancers interact with specific proteins called transcription factors, which bind to DNA and initiate gene expression. Different cell types express unique sets of transcription factors, leading to cell-specific enhancer activity. This orchestrated interplay between enhancers and transcription factors establishes and maintains cellular identity.

Enhancer Misregulation in Cancer: In cancer, enhancers can become misregulated, disrupting the normal gene expression patterns. This disruption can result from various abnormalities, such as mutations in enhancer sequences, changes in transcription factor expression, or alterations in epigenetic modifications that control enhancer accessibility.

Oncogenic Enhancers: Some enhancers, termed oncogenic enhancers, exhibit abnormally high activity in cancer cells. These enhancers drive the expression of genes that promote cancer growth, proliferation, and invasion. Identifying and targeting oncogenic enhancers could provide promising therapeutic avenues for cancer treatment.

Enhancer Silencing in Cancer: Conversely, other enhancers may be silenced in cancer cells, leading to the loss of expression of genes that suppress tumor growth. Restoring the activity of these silenced enhancers could potentially halt cancer progression.

Targeting Enhancers in Cancer: The development of therapies that target enhancers holds significant promise for cancer treatment. By manipulating enhancer activity, researchers aim to restore normal gene expression patterns, suppress cancer cell growth, and promote tumor regression.

Epigenetic Modifications and Enhancers: Epigenetic modifications, such as DNA methylation and histone modifications, can influence enhancer activity. By altering the accessibility of enhancers to transcription factors, epigenetic changes contribute to the dysregulation of gene expression in cancer.

Chromatin Structure and Enhancers: The three-dimensional organization of chromatin, the complex of DNA and proteins that make up chromosomes, also affects enhancer function. Alterations in chromatin structure can disrupt enhancer-promoter interactions, leading to aberrant gene expression.

Modeling Enhancer Regulation: Computational and experimental approaches are employed to decipher the intricate regulation of enhancers in cancer. These models help identify key transcription factors, enhancer elements, and chromatin modifications involved in oncogenesis.

Future Directions: Ongoing research is focused on understanding the mechanisms underlying enhancer misregulation in cancer, developing novel therapeutic strategies that target enhancers, and utilizing computational tools to predict and modulate enhancer activity.

Conclusion: Enhancers play a pivotal role in maintaining cellular identity and are often dysregulated in cancer. Targeting enhancers offers a promising approach for cancer treatment, with potential implications for precision medicine and the development of more effective therapies. Further research is needed to fully unravel the complexities of enhancer regulation and harness their potential for combating cancer.

The emerging role of super enhancerderived noncoding RNAs in human cancer
Regulation of Cellular Identity during Cancer Progression The Snyder Lab snyder pause ucsf
Genes Free FullText Genomic Enhancers in Brain Health and Disease
Novel principle for cancer treatment shows promising effect cancer principle effect treatment novel promising shows expression crisis molecule dna cells mitochondrial inhibitors cellular cause target energy green small
Genomic Views of Transcriptional Enhancers Essential Determinants of
Frontiers From SuperEnhancer Noncoding RNA to Immune Checkpoint enhancer super rna enhancers immune non frontiersin functions checkpoint coding frameworks figure fonc
Comparative DNA methylome analysis of endometrial carcinoma reveals endometrial enhancers promoters dna comparative methylome distinct deregulation carcinoma
Molecules Free FullText PPARs as Nuclear Receptors for Nutrient metabolism ppars energy molecules nuclear
Frontiers Targeting SuperEnhancers as a Therapeutic Strategy for super enhancers enhancer cancer targeting frontiersin therapeutic strategy treatment figure fphar
Who am I Can a cellular identity crisis lead to cancer progression? emt epithelial mesenchymal transition identity cellular progression crisis cancer lead cells
Genomic Views of Transcriptional Enhancers Essential Determinants of enhancers cns cellular dependent determinants genomic transcriptional identity
Frontiers Functions and Clinical Significance of SuperEnhancers in enhancers frontiersin clinical diseases significance fcell
Identity vs role confusion definition. Identity vs Role Confusion. 2022
Genomic Views of Transcriptional Enhancers Essential Determinants of genomic determinants cns transcriptional dependent cellular identity enhancers responses essential activity views figure
JCM Free FullText VasoOcclusion in Sickle Cell Disease Is sickle occlusion microvasculature jcm autonomic trigger dysregulation
Genomic Views of Transcriptional Enhancers Essential Determinants of activity enhancers transcriptional cns genomic identity responses dependent determinants cellular essential views figure jneurosci
Heart disease leukemia linked to dysfunction in nucleus Salk disease nucleus cell dysfunction salk identity heart related leukemia linked nuclear disorders omics through gene pore
Genes Free FullText Super Enhancers in Cancers Complex Disease super enhancers developmental disorders disease cancers complex figure genes
Role of Epigenetics in Cardiac Development and Congenital Diseases cohesin regulation
Frontiers DNA methylation dynamics in muscle development and disease methylation dna cpg island frontiersin cell type disease dynamics muscle development aging figure specific fnagi
Active Motif's Epigenetic Services group now offers SuperEnhancer Services super enhancer profiling targets antibodies known se activemotif
Figure 1 from Regulation of Cellular Identity in Cancer. Semantic Scholar

Post a Comment for "Title: Cellular Identity Crisis: The Role of Enhancers in Cancer"